The other Janus face of Qa-1 and HLA-E diverse peptide repertoires in times of stress

Author(s):
Hall, T. van (0000-0002-9115-558X); Oliveira, C.C.; Joosten, S.A. (0000-0002-9878-0863); Ottenhoff, T.H.M. (0000-0003-3706-3403)
Published
2010
Publication type
Article / Letter to editor

Abstract

The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity Under stress this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins infectious agents or antigen processing defects (C) 2010 Institut Pasteur Published by Elsevier Masson SAS All rights reserved

MHC Ib Qa 1 HLA E M tuberculosis Tumorimmunology Processing defects natural-killer-cells class ib molecule cd8(+) t-cells sequence-derived peptides e surface expression human cytomegalovirus nk cells binding-specificity intramembrane proteolysis signal sequences
Date issued
2010-11-30
Language
English
Is part of
Microbes and Infection (2010), Vol. 12, no. 12-13, p. 910-918
hdl
1887/109532