Elsevier Trophoblast Research Award Lecture: Unique Properties of Decidual T Cells and their Role in Immune Regulation during Human Pregnancy

Author(s):
Tilburgs, T.; Claas, F.H.J. (0000-0003-4157-6201); Scherjon, S.A.
Published
2010
Publication type
Article / Letter to editor

Abstract

Maternal lymphocytes at the fetal-maternal interface play a key role in the immune acceptance of the allogeneic fetus. Most studies focus on decidual NK cells and their interaction with fetal trophoblasts, whereas limited data are available on the mechanisms of fetus specific immune recognition and immune regulation by decidual T cells at the fetal-maternal interface. The aim of this review is to describe the phenotypic characteristics of decidual T cell subsets present at the fetal-maternal interface, their interaction with HLA-C expressed by fetal trophoblasts and their role in immune recognition and regulation at the fetal-maternal interface during human pregnancy. (C) 2010 Published by IFPA and Elsevier Ltd.

Human Decidua T cells HLA-C CD4+CD25(bright) invariant nkt cells peripheral-blood spontaneous-abortion cd4(+) cd25(bright) maternal tolerance fetal rejection antigens transplantation cd4(+)cd25(+) expansion
Date issued
2010-03-31
Language
English
Is part of
Placenta (2010), Vol. 31, p. S82S86
hdl
1887/109518