'In vivo' optical approaches to angiogenesis imaging

Author(s):
Snoeks, T.J.A.; Lowik, C.W.G.M.; Kaijzel, E.L.
Published
2010
Publication type
Article / Letter to editor

Abstract

In recent years, molecular imaging gained significant importance in biomedical research. Optical imaging developed into a modality which enables the visualization and quantification of all kinds of cellular processes and cancerous cell growth in small animals. Novel gene reporter mice and cell lines and the development of targeted and cleavable fluorescent "smart" probes form a powerful imaging toolbox. The development of systems collecting tomographic bioluminescence and fluorescence data enabled even more spatial accuracy and more quantitative measurements. Here we describe various bioluminescent and fluorescent gene reporter models and probes that can be used to specifically image and quantify neovascularization or the angiogenic process itself.

Angiogenesis Bioluminescence Fluorescence Molecular imaging Optical imaging endothelial growth-factor green fluorescent protein reporter gene-expression rgd-modified proteins tumor angiogenesis quantum dots living mice mouse model bioluminescence tomography integrin alpha(v)beta(3)
Date issued
2010-06-30
Language
English
Is part of
Angiogenesis (2010), Vol. 13, no. 2, p. 135-147
hdl
1887/109071
doi
10.1007/s10456-010-9168-y