Dendritic Cells as a Tool to Induce Transplantation Tolerance: Obstacles and Opportunities

Author(s):
Kooten, C. van (0000-0002-6257-0899); Lombardi, G.; Gelderman, K.A.; Sagoo, P.; Buckland, M.; Lechler, R.; Cuturi, M.C.
Published
2011
Publication type
Article / Letter to editor

Abstract

Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.

Dendritic cells Tolerance Cellular therapy regulatory t-cells antigen-presenting cells heme oxygenase-1 renal-transplantation organ-transplantation allograft tolerance suppressor-cells indirect pathway lymph-nodes in-vivo
Date issued
2011-01-15
Language
English
Is part of
Transplantation (2011), Vol. 91, no. 1, p. 2-7
hdl
1887/108596