Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s)

Codon-constrained Val-Ala (COCO-VA) togglingCovariationIntrinsically disordered proteinMiddle T antigenSmall T antigenAlternative T antigenPhylogenyPolyomavirusPolyomavirus adaptation to human populationPositive selectionShort linear motifSLiMTrichodysplasia spinulosa-associated polyomavirusTSPyV