P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice

Author(s):
Tang, S.C.; Kort, A.; Cheung, K.L.; Rosing, H.; Fukami, T.; Durmus, S.; Wagenaar, E.; Hendrikx, J.J.M.A.; Nakajima, M.; Vlijmen, B.J.M. van; Beijnen, J.H.; Schinkel, A.H.
Published
2015
Publication type
Article / Letter to editor
cabazitaxelcarboxylesterasepharmacokineticsP-glycoproteinbrain accumulation
Date issued
2015-10-31
Language
English
Is part of
Molecular Pharmaceutics (2015), Vol. 12, no. 10, p. 3714-3723
hdl
1887/106767
doi
10.1021/acs.molpharmaceut.5b00470