P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice

Author(s):
Tang, S.C.; Sparidans, R.W.; Cheung, K.L.; Fukami, T.; Durmus, S.; Wagenaar, E.; Yokoi, T.; Vlijmen, B.J.M. van; Beijnen, J.H.; Schinkel, A.H.
Published
2014
Publication type
Article / Letter to editor
Date issued
2014-06-15
Language
English
Is part of
Clinical Cancer Research (2014), Vol. 20, no. 12, p. 3133-3145
hdl
1887/105148
doi
10.1158/1078-0432.CCR-13-1759