Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Author(s):
Ritfeld, G.J.; Tewarie, R.D.N.; Rahiem, S.T.; Hurtado, A.; Roos, R.A.; Grotenhuis, A.; Oudega, M.
Published
2010
Publication type
Article / Letter to editor

Abstract

We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point survival 7 days later was similar between treatment groups and saline-injected controls. In fact we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion. NeuroReport 21:221-226 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

bone marrow stromal cell cell survival cell transplantation macrophages spinal cord injury trauma mesenchymal stem-cells paraplegic rats cyclosporine-a injury recovery apoptosis growth death
Date issued
2010-02-17
Language
English
Is part of
NeuroReport (2010), Vol. 21, no. 3, p. 221-226
hdl
1887/104017
doi
10.1097/WNR.0b013e32833677cd