Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

Author(s):
Bremer, E.T.J. van den; Beurskens, F.J.; Voorhorst, M.; Engelberts, P.J.; Jong, R.N. de; Boom, B.G. van der; Cook, E.M.; Lindorfer, M.A.; Taylor, R.P.; Berkel, P.H.C. van; Parren, P.W.H.I. (0000-0002-4365-3859)
Published
2015
Publication type
Article / Letter to editor
complement activationherapeutic antibodypost-translational controlADCCantibody-dependent cell-mediated cytotoxicityCDCcomplement-dependent cytotoxicityCEXcation-exchangecIEFcapillary isoelectric focusingCPBcarboxy peptidase BESI-MSelectrospray ionization mass spectrometryIEFisoelectric focusingSDS-PAGEsodium dodecyl sulfate polyacrylamide gel electrophoresis
Date issued
2015-07-04
Language
English
Is part of
mAbs (2015), Vol. 7, no. 4, p. 672-680
hdl
1887/104000
doi
10.1080/19420862.2015.1046665