Glycoforms of Immunoglobulin G Based Biopharmaceuticals Are Differentially Cleaved by Trypsin Due to the Glycoform Influence on Higher-Order Structure

Author(s):
Falck, D. (0000-0003-3908-2376); Jansen, B.C.; Plomp, R.; Reusch, D.; Haberger, M.; Wuhrer, M. (0000-0002-0814-4995)
Published
2015
Publication type
Article / Letter to editor
glycoproteomicsglycosylationtrypsin substrate specificitytryptic cleavagebiopharmaceuticalsimmunoglobulin Gmonoclonal antibodiesmethod developmenthigher-order structureproteolytic biases
Date issued
2015-09-30
Language
English
Is part of
Journal of Proteome Research (2015), Vol. 14, no. 9, p. 4019-4028
hdl
1887/101088
doi
10.1021/acs.jproteome.5b00573