Structure-guided discovery of cis-hexahydro-pyrido-oxazinones as reversible, drug-like monoacylglycerol lipase inhibitors

Author(s):: Kuhn, B.; Ritter, M.; Hornsperger, B.; Bell, C.; Kocer, B.; Rombach, D.; Lutz, M.D.R.; Gobbi, L.; Kuratli, M.; Bartelmus, C.; Burkler, M.; Koller, R.; Tosatti, P.; Ruf, I.; Guerard, M.; Pavlovic, A.; Stephanus, J.; O'Hara, F.; Wetzl, D.; Saal, W.; Stihle, M.; Roth, D.; Hug, M.; Huber, S.; Heer, D.; Kroll, C.; Topp, A.; Schneider, M.; Gertsch, J.; Glasmacher, S.; Stelt, M. van der (0000-0002-1029-5717); Martella, A. (0000-0002-4680-7702); Wittwer, M.B.; Collin, L.; Benz, J.; Richter, H.; Grether, U.

Date issued: 2024-10-03
Language: English
Is part of: Journal of Medicinal Chemistry (2024), Vol. 67, no. 20, p. 18448-18464
hdl: 1887/4175171
doi: 10.1021/acs.jmedchem.4c01769