The use of activity based protein profiling to study proteasome biology

Author(s):
Paniagua Soriano, Guillem
Published
2016
Publication type
Doctoral Thesis

Abstract

The work described in this thesis focuses on the characterization of proteasome directed activity-based probes (ABPs) as well as on the adaptation mechanisms that make multiple myeloma derived cell lines resistant against proteasome inhibitors (PIs).

Multiple MyelomaABPPProteasome inhibition
Defense date
2016-02-11
Language
English
Supervisor(s)
Overkleeft, H.S.
Advisor(s)
Florea, B.I.
Qualification
Ph.D.
Degree granting institution
Faculty of Science, Leiden University, Leiden
hdl
1887/37766